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- Delivering cancer treatment on a nanodisc helps eliminate tumors
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Rui Kuai and Dr. Wenmin Yuan In the wrestling match with cancer, chemoimmunotherapy is the new strong arm, and it is building muscle with a nanodisc disguised as "good cholesterol.
The nanodisc is made of a synthetic version of high density lipoprotein HDLalso known as " good cholesterol. Moon, Ph.
In multiple mouse tumor models of colon cancer, researchers found up to 85 percent of the tumors were completely eliminated when combining the nanodisc-delivered chemotherapy with immune checkpoint blockers, a common immunotherapy treatment.
In a more challenging model of cancer, one that metastasized to the liver, the treatment also showed an excellent response rate of 88 percent. To determine if cells are harmful to the body and need to be attacked, the immune system uses certain molecules called checkpoints. But some cancer cells avoid an immune system attack by producing proteins that trick the checkpoints.
Provides state of the art information on surgery, oncology, imaging, staging, pathology, and palliation Explains how to organize the multidisciplinary team Addresses key colorectal cancer new treatments Aids understanding and communication among team members About this book This book is intended as the equivalent of the Swiss Army knife for all members of colorectal cancer CRC multidisciplinary teams and those training in the fields of CRC management. It describes how to organize the team and explains the basic principles within the different disciplines involved in the treatment and care of CRC patients. Important, up-to-date knowledge is provided on visualization techniques, surgery, oncological treatment, palliation, and pathology, with special focus on controversies and aspects of interest to all team members. Care has been taken to ensure that each specialty-specific chapter will be approachable for team members from other specialties or professions, thereby facilitating an effective interdisciplinary approach to teamwork.
Checkpoint blockers were designed to allow immune cells to kill cancer cells. These immunotherapy treatments are highly successful in some patients, but only about 20 percent will benefit.
Объяснив, что здешняя система озер поставляет октопаукам почти половину всего запаса пресной воды.
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Вилли уже хлюпал носом и смотрел в землю.
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By using the synthetic HDL, which mimics natural HDL in the body, the researchers were able to hide the chemotherapy from the immune system. James Moon, Ph.
Credit: University of Michigan College of Pharmacy "When we attached the chemotherapy drug to colorectal cancer new treatments synthetic HDL, we saw significant improved circulation half-life, improved delivery to the tumor cells and a better accumulation of the drug in the tumor cells," says study co-senior author Anna Schwendeman, Ph.
The immune system was empowered to recognize and attack tumor cells.
There were no overt side effects to the new delivery system. Colorectal cancer new treatments interestingly, the researchers discovered another unexpected benefit: less impact on the heart.
But we found that by delivering doxorubicin on the synthetic HDL nanodisc, we saw better accumulation of the drug in the tumor and we didn't detect any cardiotoxicity," Schwendeman says. That may have contributed to the absence of cardiotoxicity," she adds, noting that more research is needed to confirm that speculation.
Our results demonstrating their efficacy in multiple tumor models suggest that our strategy may have wide applications in multiple cancer types," Moon says. Phase I clinical trials have been conducted for the synthetic HDL nanodisc, which has been determined to be safe, Moon says.
Next, the researchers are working to test the therapy on humans in clinical trials. Explore further More information: "Elimination of established tumors with nanodisc-based combination chemoimmunotherapy" Science Advances Colorectal cancer new treatments Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission.
The content is provided for information purposes only.
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- Aceste exemple pot conține termeni colocviali.