The biologic behavior of squamous cervical carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to cervical cancer metastatic sites treatment have not been thoroughly investigated.
The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance. The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy.
Our results demonstrate that the evaluation of CD44v6 immunoexpression cervical cancer metastatic sites cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness.
The high level of E-cadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with cervical cancer metastatic sites on the outcome. A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide a better characterization of the tumor response to neoadjuvant therapy, with a positive prognosis impact.
Facing such a scenario, the only solution is following a sequence of investigations and therapy steps towards a correct and complete diagnosis if possible.
Int J Cancer ; Rom J Morphol Embryol ; CD44 isoform 6 CD44v6 is a prognostic indicator of the response to neoadjuvant chemotherapy in cervical carcinoma.
Gynecol Oncol ; 80 1 CD 44 exon v6 as a predictor of lymphatic metastases in cervical cervical cancer metastatic sites immunocytochemical study of 94 cases. Arch Gynecol Obstet ; 3 Immunohistochemical detection of adhesion molecule CD44 splice variants in lymph node metastases of cervical cervical cancer metastatic sites.
Int J Cancer ; 69 3 CD44 is an independent prognostic factor in early-stage cervical cancer. Int J Cancer ; 74 2 E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma.
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Gynecol Oncol ; Braz Dent J ; 20 1 Anticancer Res ; Altered expression and cervical cancer metastatic sites of E-cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinoma. J Pathol ; 2 Complex networks orchestrate epithelial-mesenchymal transitions.
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Cervical Cancer: What To Know
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