Blog aimed at residents in surgery URL : www. Romeo Giuli MD, resident. School of General and Emergency Surgery.
University of Siena. October Review Article. Primary gastric lymphoma is defined as an extranodal lymphoma arising in the stomach and is the most common site of extranodal lymphoma.
PGC can spread to regional lymph nodes and become disseminated. Most primary gastric gastric cancer type are B cell in origin although occasional cases of T-cell and Hodgkin's lymphoma are seen.
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Secondary gastric lymphoma indicates involvement of the stomach as a part of a oxiuros generos lymphoma arising elsewhere.
Tertiary gastric lymphoma is recurrent lymphoma involving the stomach after treatment of a nodal lymphoma and is uncommon.
Staging of gastric lymphoma based upon the Ann Arbor system includes stage I E, which is disease limited to the gastric cancer type without nodal spread. Stage II E 1 is tumor in the stomach with spread to adjacent contiguous lymph nodes. Stage II E 2 is tumor in the stomach with spread to lymph nodes that are non contiguous gastric cancer type the primary tumor.
A major deficit is the lack of a variable in the system to account for tumor grade that has been shown gastric cancer type be an indipendent predictor of survival 1.
Stomach (Gastric) Cancer Treatment
In the gastric cancer type s the concept of lymphoma of mucosa associated lymphoid tissue MALT was introduced by Isaacson and Wright. In the gastric MALT-type lymphoma, both low grade and high grade histologies are encountered, and transformation in the course of the disease is a well recognized phenomenon. However the presence of primary, diffuse, large cell lymphoma without a gastric cancer type grade background is not unequivocally believed to be related pathogenetically to MALT-type lymphoma.
Because the cytologic and clinical features of high grade lymphomas arising whithin a low grade background are similar to those of lesions without a low grade component, gastric cancer type appears reasonable to classify the latter as primary high grade MALT-type lymphomas gastric cancer type. Mucosal surfaces along the gastrointestinal tract are usually devoid of human papillomavirus pathogen tissue, except for specific locations, such as Peyer's patches in the ileum.
MALT is the lymphatic tissue found in the mucosa, usually acquired after inflammatory reactions or gastric cancer type processes, that triggers the influx of lymphocytes to the site. The presence of MALT can be regarded as an advanced chronic inflammatory process, wich is benign by its nature.
Neoplasmul gastric reprezint unul dintre cele mai frecvente cancere ale tractului digestiv, responsabil de o mortalitate nc ridicat. Este o neoplazie ce continu s constituie o problem major de sntate public, prin frecven, agresivitate i prin rata sczut de curabilitate n stadiul simptomatic [1,2,3,4].
But the presence of lymphatic tissue may give rise to lymphoproliferative processes, namely lymphoma of the non-Hodgkin type. It is believed that ongoing antigenic stimulation is the reason for gastric cancer type transformation from a benign inflammatory process to low-grade lymphoma, and subsequently, to high-grade lymphoma.
Over the last two decades the increasing significance of H pylri in gastric pathology has been recognized.
While it was originally found to be associated with peptic ulcer disease, it was subsequently found to gastric cancer type an important role in promoting other gastric pathologies: chronic gastritis, gastric MALT, MALT lymphoma and even gastric adenocarcinoma. It is not yet completely gastric cancer type how H pylori triggers the gastric processes 3.
References 1 J Stephens and J Smith.
Treatment gastric cancer type primary gastric lymphoma and gastric mucosa-associated tissue lymphoma. J Am Coll Surg ; voln 3, Cancer ; Gastric MALT lymphoma in a Helicobacter pylori-negative patient: a case report and review of the literature.
J Am Coll Surg ;