High risk hpv leads to cancer


Ginecologie minim-invaziva 1 Apply Ginecologie minim-invaziva filter HPV și cancerul de col uterin HPV - Human Papilloma Virus — este un virus comun care se transmite prin contact sexual vaginal, oral sau anal. Infecţia persistentă cu HPV reprezintă cauza principală a cancerului de col uterin. Sunt descrise aproape 40 de genotipuri care pot fi localizate la nivelul organelor genitale atât la bărbat, cât şi la femeie, precum şi în faringe şi cavitatea bucală, determinând infecţii asimptomatice. Genotipurile diferă prin gradul de risc conferit post-infecţie pentru dezvoltarea cancerului: genotipuri de HPV cu grad ridicat high risk hpv leads to cancer risc - high risk - determină la femei modificări ale celulelor de la nivelul zonei cervico-vaginale şi pot duce la dezvoltarea cancerului de col uterin genotipuri de HPV cu grad scăzut de risc - low risk -  pot duce la apariţia condiloamelor acuminate condilomatoza genitală De cele mai multe ori sistemul imun reuşeşte să elimine virusul în aproximativ 2 ani, înainte ca acesta să producă probleme de sănatate. Persistenţa infecţiei cu HPV pentru mai mulţi ani poate să  duca la apriţia cancerul de col uterin.

Department of Ophthalmology, Grigore T. E-mail: moc.

The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence high risk hpv leads to cancer cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. Uncontrolled cell proliferation leads to increased risk of genetic instability.

We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye. The method used for the detection of HPV was real time polymerase chain reaction.

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The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence. Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase chain reaction, squamous cell carcinoma Human papillomavirus HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.

The association between HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells.

Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation high risk hpv leads to cancer redness in the left eye for almost 1-year and a half.

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He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist. The patient admits being a heavy smoker for almost 30 years and that in his free time he practices agriculture without using sunglasses.

All other ophthalmological findings were high risk hpv leads to cancer.

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Conjunctival culture was performed before surgery, and no bacterial infection was found. The CT scan of the head and neck showed no signs high risk hpv leads to cancer tumor invasion of the orbit or the lymph nodes. The limbic lesion was removed surgically with cura detoxifiere brasov mm margin of normal tissue and diathermy of the adjacent sclera was done.

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At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor was cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.

Histopathology exam showed a moderate differentiated keratinized high risk hpv leads to cancer cell carcinoma of the conjunctiva without koilocytosis [Figs.