Hpv high risk non-16/18, Case Report


Metodele de testare pentru HPV cunoscute pina in prezent prezinta dezavantaje care nu trebuie neglijate: detecteaza un numar relativ mic de tipuri de HPV comparativ cu cele existente 37 de tipuri, fata de cele peste de tipuri cunoscutese aplica doar pentru prelevate cervicale in mediu lichid excluzind astfel leziunile anale, oro-faringiene, conjunctivale, epidermice, laringealeau hpv high risk non-16/18 limitata pentru unele tipuri, limita de detectie ajunge si la de copii ADN, ceea ce sugereaza un numar relativ hpv high risk non-16/18 de cazuri fals negative, datorate fie recoltarii unui numar mic de celule, fie infectarii cu virus a unui numar mic de celule. Laboratoarele synlab utilizeaza acum o metoda de testare a HPV care exclude toate aceste inconveniente. Virusurile Papilloma sint virusuri ADN din grupul papovavirusuri. Se cunosc peste de tipuri diferite, care patrund in celulele gazda prin microleziuni ale epidermei si mucoasei.

Department of Ophthalmology, Grigore T. E-mail: moc. We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye.

The method used for the detection of HPV was real time polymerase chain reaction. The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence.

Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase chain reaction, squamous cell carcinoma Human papillomavirus Hpv hpv high risk non-16/18 risk non-16/18 infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and neck cancers oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell carcinoma.

hpv high risk non-16/18

The association hpv high risk non-16/18 HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells.

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Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in hpv high risk non-16/18 left eye for almost 1-year and a half.

He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist. The patient admits being a heavy smoker for almost 30 years and that in his free cancerul de piele pete he practices agriculture without using sunglasses.

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All other ophthalmological findings were normal. Conjunctival culture was performed before surgery, and hpv high risk non-16/18 bacterial infection was found.

Ginecologie minim-invaziva 1 Apply Ginecologie minim-invaziva filter HPV și cancerul de col uterin HPV - Human Papilloma Virus — este un virus comun care se transmite prin contact sexual vaginal, oral sau anal. Infecţia persistentă cu HPV reprezintă cauza principală a cancerului de col uterin. Sunt descrise hpv high risk non-16/18 40 de genotipuri care pot fi localizate la nivelul organelor genitale atât la bărbat, cât şi la femeie, precum şi în faringe şi cavitatea bucală, determinând infecţii asimptomatice. Genotipurile diferă prin gradul de risc conferit post-infecţie pentru dezvoltarea cancerului: genotipuri de HPV cu grad ridicat de risc - high risk - determină la femei modificări ale celulelor de la nivelul zonei cervico-vaginale şi pot duce la dezvoltarea cancerului de col uterin genotipuri de HPV cu grad scăzut de risc - low risk hpv high risk non-16/18  pot duce la apariţia condiloamelor acuminate condilomatoza genitală De cele mai multe ori sistemul imun reuşeşte să elimine virusul în aproximativ 2 ani, înainte ca acesta să producă probleme de sănatate. Persistenţa infecţiei cu HPV pentru mai mulţi ani poate să  duca la apriţia cancerul de col uterin.

The CT scan of the head and neck showed no signs of tumor invasion of the orbit or the lymph nodes. The limbic lesion was removed surgically hpv high risk non-16/18 2 mm margin of normal tissue and diathermy of the adjacent sclera was done.

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At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised hpv high risk non-16/18 was cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated hpv high risk non-16/18 4°C until processing.

Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.