All of Opin vísindi
Abstract Cancer familial syndromes to describe two cases of familial papillary thyroid carcinoma. Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first case and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case.
Results and discussion: case presentation: first case, 68 years old man had a colonic polyposis attenuated form with only a few polyps and a thyroid nodule. After hemicolectomy for a supposed colonic carcinoma with liver and lung metastases, histological examination revealed no malignant colonic disease. Two month later the diagnosis of invasive thyroid tumor with lymph node metastases was made, but only an cancer familial syndromes biopsy was done because tumor invasiveness demonstrated on MTI imaging.
This type of cancer has a high mortality, and the overall survival is also low. In these conditions, researchers are always cancer familial syndromes for improving the therapy. In this presentation, we mention the histological types of pancreatic cancer, the importance of systemic therapy for operable cases pre- and post-surgeryand of chemotherapy for advanced and metastatic cancer. New therapeutic agents have been introduced, that appear to give new hope for a more efficient treatment. Acest cancer are o mortalitate ridicată, iar supravieţuirea globală este de asemenea scăzută.
The biopsy identified a papillary thyroid carcinoma. Case 2: the son cancer familial syndromes the patient 30 years old without known diseases was invited cancer familial syndromes be assessed for thyroid disease. Ultrasound examination discovered a large nodule with microcalcifications. Microscopic cancer familial syndromes done after total thyroidectomy revealed a cribriform morular variant of papillary thyroid cancer familial syndromes, a variant that is cancer familial syndromes to be associated with FAP.
Radioiodine ablation was made followed by suppressive thyroxine treatment. In the second case adenomatous polyposis was not found yet.
Browsing Háskóli Íslands by Author "Jinga, Viorel"
In our knowledge these are the first cases of familial thyroid papillary carcinomas in our setting. Familial history allowed an earlier diagnosis and a good cancer familial syndromes of the disease in the second case. Conclusions: according to the literature and our first experience, screening for thyroid cancer must be done in all patients with FAP and in those with a FAP proband in the family. Nosé V. Endocr Pathol.
Modern Pathology ; SS Cavaco BM. Endocrine-Related Cancer ; Richards ML. Thyroid ; Nilbert M, Kristoffersson U, Ericsson M, et al: Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at cancer familial syndromes BMC Med Genet. Orphanet J Rare Dis ; 7.
Revista Societatii de Medicina Interna
Histopathology ; Asian J Surg. Clin Gastroenterol Hepatol. Clin Colorectal Cancer ; 11 4 : Head Neck ; Ann Surg. Kameyama K, Takami H.
Although the causes of this disease are not entirely understood, it is known that several factors influence its occurrence.
Fam Cancer. Lee S, Hong SW, Shin SJ,et al: Papillary thyroid carcinoma associated with familial adenomatous polyposis: molecular analysis of pathogenesis in a family and review of cancer testicular stage 3 literature.
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Endocr J. Am J Otolaryngol. Cetta F. Acta Cytol. Kurihara K, Cancer familial syndromes S, Chong J, et al: Nuclear localization of immunoreactive beta-catenin is specific to familial adenomatous polyposis in papillary thyroid carcinoma.
Jpn J Cancer Res. Ito Y, Miyauchi A, Ishikawa H, et al: Cancer familial syndromes experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients.
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